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The receptor then desensitizes speedily and enters in a transient inactive state, characterized via the presence of bound agonist (By similarity). During the presence of CACNG4 or CACNG7 or CACNG8, displays resensitization that is characterised by a delayed accumulation of current flux on ongoing application of L-glutamate (By similarity). Through complicated formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR as well as the endosomal sorting with the GRIA2 subunit toward recycling and membrane targeting (By similarity)

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Soon after binding acetylcholine, the AChR responds by an in depth transform in conformation that has an effect on all subunits and causes opening of the ion-conducting channel over the plasma membrane permeable to sodium ions

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